{"exhaustive":{"nbHits":true,"typo":true},"exhaustiveNbHits":true,"exhaustiveTypo":true,"hits":[{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"wslh"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"RevMed's Pancreatic Cancer Pill Priced Above $475,000 a Year"},"url":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"https://www.bloomberg.com/news/articles/2026-08-26/fda-approves-revmed-s-breakthrough-pill-for-pancreatic-cancer"}},"_tags":["story","author_wslh","story_49455836"],"author":"wslh","children":[49456116],"created_at":"2026-08-26T21:00:07Z","created_at_i":1787778007,"num_comments":1,"objectID":"49455836","points":11,"story_id":49455836,"title":"RevMed's Pancreatic Cancer Pill Priced Above $475,000 a Year","updated_at":"2026-08-28T04:53:56Z","url":"https://www.bloomberg.com/news/articles/2026-08-26/fda-approves-revmed-s-breakthrough-pill-for-pancreatic-cancer"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"hentrep"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"RevMed receives early FDA approval for 'groundbreaking' pancreatic cancer drug"},"url":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"https://www.biospace.com/drug-development/revmed-receives-early-fda-approval-for-groundbreaking-pancreatic-cancer-drug"}},"_tags":["story","author_hentrep","story_49451476"],"author":"hentrep","children":[49451557],"created_at":"2026-08-26T16:05:09Z","created_at_i":1787760309,"num_comments":1,"objectID":"49451476","points":4,"story_id":49451476,"title":"RevMed receives early FDA approval for 'groundbreaking' pancreatic cancer drug","updated_at":"2026-08-26T21:15:53Z","url":"https://www.biospace.com/drug-development/revmed-receives-early-fda-approval-for-groundbreaking-pancreatic-cancer-drug"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"cleguy95"},"story_text":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"As the title says, I'm a SE at a mid-size ($100-$200m rev) med device contract manufacturer. It's cool to play a part in how data is collected/analyzed/managed here. We have a strong mfg eng culture, but SE/data mgmt has not been a high priority until I arrived, which can make my job frustrating.\nI've done cool projects with .Net stack that clct/org/anlyze data from the factory. I was alone for about two years and after much convincing, we recently hired a second SE.

I started my career on an agile team at a marketing tech co, then built dapps at crypto consultancy with Node/React/Solidity and did product dev, tech writing, architecture and engineering. I found that I love going through the full SDLC to build something interesting/valuable. Then I did some consulting and ended up in my current gig that way.

I love the idea of helping a legacy mfg co modernize their digital ops-especially a company that makes the stuff that we make. But, it is frustrating. I have a lot of reg documentation, long approval times, and training users how to use the software and getting their feedback... which isn't bad... everyone is nice and it's a change of pace from a typical environment where you rarely get to interact with your users.

At times, I find myself questioning if this is a good position for my career. I have an atypical background (been interested in econ for a while, did equity rsrch for a hedge fund in high school/freshman yr, left school after death in fam, did bootcamp instead of more college) but I love learning, and I read tech blogs, etc. every day. I stay in touch with the veteran SEs I've worked with in the past and for advice, but a lot of times I still question if I'm doing the right thing for myself, the company I'm at, and now the engineer we recently hired....

So HN: does anyone have experience working with/for a legacy manufacturer trying to improve their digital ops? Also, what advice might you have for my career path?

Cheers."},"title":{"matchLevel":"none","matchedWords":[],"value":"Ask HN: Career advice for software engineer/analyst at med-tech manufacturer"}},"_tags":["story","author_cleguy95","story_26889689","ask_hn"],"author":"cleguy95","children":[26889892,26890180,26915157],"created_at":"2021-04-21T13:52:47Z","created_at_i":1619013167,"num_comments":5,"objectID":"26889689","points":14,"story_id":26889689,"story_text":"As the title says, I'm a SE at a mid-size ($100-$200m rev) med device contract manufacturer. It's cool to play a part in how data is collected/analyzed/managed here. We have a strong mfg eng culture, but SE/data mgmt has not been a high priority until I arrived, which can make my job frustrating.\nI've done cool projects with .Net stack that clct/org/anlyze data from the factory. I was alone for about two years and after much convincing, we recently hired a second SE.

I started my career on an agile team at a marketing tech co, then built dapps at crypto consultancy with Node/React/Solidity and did product dev, tech writing, architecture and engineering. I found that I love going through the full SDLC to build something interesting/valuable. Then I did some consulting and ended up in my current gig that way.

I love the idea of helping a legacy mfg co modernize their digital ops-especially a company that makes the stuff that we make. But, it is frustrating. I have a lot of reg documentation, long approval times, and training users how to use the software and getting their feedback... which isn't bad... everyone is nice and it's a change of pace from a typical environment where you rarely get to interact with your users.

At times, I find myself questioning if this is a good position for my career. I have an atypical background (been interested in econ for a while, did equity rsrch for a hedge fund in high school/freshman yr, left school after death in fam, did bootcamp instead of more college) but I love learning, and I read tech blogs, etc. every day. I stay in touch with the veteran SEs I've worked with in the past and for advice, but a lot of times I still question if I'm doing the right thing for myself, the company I'm at, and now the engineer we recently hired....

So HN: does anyone have experience working with/for a legacy manufacturer trying to improve their digital ops? Also, what advice might you have for my career path?

Cheers.","title":"Ask HN: Career advice for software engineer/analyst at med-tech manufacturer","updated_at":"2024-09-20T08:27:18Z"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"yboris"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"Builder's Remedy goes into effect in many California cities tomorrow"},"url":{"matchLevel":"none","matchedWords":[],"value":"https://darrellowens.substack.com/p/ca-cities-to-lose-all-zoning-powers"}},"_tags":["story","author_yboris","story_34597507"],"author":"yboris","children":[34597602,34597643,34597645,34597652,34597660,34597708,34597716,34597759,34597776,34597777,34597778,34597779,34597783,34597786,34597840,34597842,34597850,34597855,34597913,34597933,34597945,34597995,34597996,34598029,34598095,34598108,34598152,34598186,34598192,34598246,34598311,34598344,34598447,34598463,34598516,34598525,34598566,34598571,34598635,34598716,34598733,34598752,34598778,34598792,34598822,34598893,34598899,34598900,34598902,34598913,34598925,34598966,34598972,34599005,34599147,34599164,34599191,34599254,34599349,34599352,34599394,34599481,34599499,34599502,34599647,34599653,34599659,34599687,34599760,34599871,34599922,34599953,34599957,34599959,34599989,34600004,34600290,34600402,34600497,34600531,34600640,34600650,34600720,34600769,34600810,34600883,34601000,34601020,34601030,34601286,34601321,34601530,34601616,34602117,34602484,34602734,34602741,34603217,34603255,34604147,34614073],"created_at":"2023-01-31T16:46:08Z","created_at_i":1675183568,"num_comments":1229,"objectID":"34597507","points":886,"story_id":34597507,"title":"Builder's Remedy goes into effect in many California cities tomorrow","updated_at":"2025-10-06T20:44:59Z","url":"https://darrellowens.substack.com/p/ca-cities-to-lose-all-zoning-powers"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"DanielBMarkham"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"We \u2018may\u2019 have discovered a potential remedy for tinnitus"},"url":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"https://www.linkedin.com/content-guest/article/we-may-have-discovered-potential-remedy-tinnitus-spencer"}},"_tags":["story","author_DanielBMarkham","story_21572827"],"author":"DanielBMarkham","children":[21573218,21573260,21573282,21573289,21573328,21573427,21573434,21573448,21573500,21573578,21573680,21574058,21574111,21574135,21574146,21574253,21574262,21574302,21574319,21574362,21574379,21574463,21574785,21574957,21574982,21575006,21575192,21575221,21575254,21575740,21575980,21576090,21576128,21576131,21576235,21576237,21576265,21576269,21576334,21576342,21576504,21576515,21576549,21576678,21576845,21576977,21577027,21577139,21577326,21577421,21577645,21577858,21578073,21578539,21578593,21578658,21579310,21579762,21579936,21580531,21580606,21580862,21593454],"created_at":"2019-11-19T13:59:54Z","created_at_i":1574171994,"num_comments":328,"objectID":"21572827","points":659,"story_id":21572827,"title":"We \u2018may\u2019 have discovered a potential remedy for tinnitus","updated_at":"2025-05-22T14:51:58Z","url":"https://www.linkedin.com/content-guest/article/we-may-have-discovered-potential-remedy-tinnitus-spencer"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"coned88"},"story_text":{"matchLevel":"none","matchedWords":[],"value":"This may seem like a silly question but it's something that's been affecting me for a while now. With the sheer amount of information available in the world today I have simply become overwhelmed. My mind is in a constant racing state. It's calm but not calm if that makes sense. While I could very well be thinking about nothing or something specific like writing this message. My mind seems to have multiple levels. One of which is directed to what I am actively doing and one below it which seems to process information in a never ending manner. I am not actively thinking about these things but it's there. Articles and books to read, shows to watch, things to do in my personal life and at work. Career advancement. All of these things just never stop but I could be calm. I can sleep fine, they don't cause active anxiety. They just linger in the background. Shooting around saying me me.

It's getting exhausting. I like to be informed. I like to know what people are talking about and like to be able to have a point of view. I like to have an opinion and be able to argue it. But I have realized it's just getting to be too much.

Currently my instapaper account has some 800 articles I have yet to read. Kindle has about 10 books I want to read. pinboard account has about 100 unread articles most of which are small books.

Any advice on what I should do? Do I just purge them?"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"Ask HN: How can I remedy scatter brain and information overload?"}},"_tags":["story","author_coned88","story_8710006","ask_hn"],"author":"coned88","children":[8710021,8710061,8710129,8710133,8710146,8710168,8710175,8710182,8710183,8710186,8710189,8710203,8710208,8710210,8710218,8710219,8710220,8710227,8710230,8710244,8710252,8710253,8710272,8710279,8710292,8710300,8710305,8710308,8710311,8710314,8710317,8710331,8710332,8710358,8710364,8710385,8710387,8710402,8710404,8710435,8710436,8710442,8710472,8710500,8710535,8710537,8710555,8710566,8710585,8710591,8710600,8710612,8710622,8710634,8710683,8710706,8710885,8710924,8710929,8710982,8710986,8710989,8710993,8711010,8711016,8711130,8711158,8711161,8711279,8711292,8711336,8711346,8711403,8711434,8711517,8711658,8711707,8711753,8711762,8711782,8711811,8711871,8711984,8712012,8712147,8712170,8712341,8712411,8712421,8712424,8712434,8712562,8712574,8712897,8713684,8715703,8715935,8715981,8716968,8717125,8718177,8719128,8724631,8729027,8731328,8741542,8745312,8747595],"created_at":"2014-12-06T20:06:50Z","created_at_i":1417896410,"num_comments":222,"objectID":"8710006","points":357,"story_id":8710006,"story_text":"This may seem like a silly question but it's something that's been affecting me for a while now. With the sheer amount of information available in the world today I have simply become overwhelmed. My mind is in a constant racing state. It's calm but not calm if that makes sense. While I could very well be thinking about nothing or something specific like writing this message. My mind seems to have multiple levels. One of which is directed to what I am actively doing and one below it which seems to process information in a never ending manner. I am not actively thinking about these things but it's there. Articles and books to read, shows to watch, things to do in my personal life and at work. Career advancement. All of these things just never stop but I could be calm. I can sleep fine, they don't cause active anxiety. They just linger in the background. Shooting around saying me me.

It's getting exhausting. I like to be informed. I like to know what people are talking about and like to be able to have a point of view. I like to have an opinion and be able to argue it. But I have realized it's just getting to be too much.

Currently my instapaper account has some 800 articles I have yet to read. Kindle has about 10 books I want to read. pinboard account has about 100 unread articles most of which are small books.

Any advice on what I should do? Do I just purge them?","title":"Ask HN: How can I remedy scatter brain and information overload?","updated_at":"2026-04-08T12:08:44Z"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"charkubi"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"1,000-year-old onion and garlic eye remedy kills MRSA"},"url":{"matchLevel":"none","matchedWords":[],"value":"http://www.bbc.co.uk/news/uk-england-nottinghamshire-32117815"}},"_tags":["story","author_charkubi","story_9290271"],"author":"charkubi","children":[9290385,9290410,9290414,9290420,9290424,9290454,9290504,9290512,9290531,9290675,9290918,9291140,9291351,9291503,9291683,9291752,9291826,9291869,9293119,9293154,9293767,9293801,9294888,9294902,9295252],"created_at":"2015-03-30T15:47:25Z","created_at_i":1427730445,"num_comments":99,"objectID":"9290271","points":227,"story_id":9290271,"title":"1,000-year-old onion and garlic eye remedy kills MRSA","updated_at":"2025-11-29T01:23:29Z","url":"http://www.bbc.co.uk/news/uk-england-nottinghamshire-32117815"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"cwwc"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy"},"url":{"matchLevel":"none","matchedWords":[],"value":"https://www.age.mpg.de/communications/news/detail/times-arrow"}},"_tags":["story","author_cwwc","story_32660669"],"author":"cwwc","children":[32661961,32661967,32661997,32662414,32662599,32662629,32662652,32662698,32662830,32663030,32663045,32663090,32663425,32663442,32663524,32663559,32663579,32663769,32663859,32664087,32664223,32664414,32664419,32664487,32664506,32664853,32664944,32665180,32665231,32665349,32665654,32666400,32668738,32670610,32670926,32671744,32672131],"created_at":"2022-08-31T11:12:49Z","created_at_i":1661944369,"num_comments":223,"objectID":"32660669","points":192,"story_id":32660669,"title":"Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy","updated_at":"2025-02-24T03:26:57Z","url":"https://www.age.mpg.de/communications/news/detail/times-arrow"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"Arathorn"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"Post-mortem and remediations for the Matrix.org security breach"},"url":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"https://matrix.org/blog/2019/05/08/post-mortem-and-remediations-for-apr-11-security-incident/"}},"_tags":["story","author_Arathorn","story_19857744"],"author":"Arathorn","children":[19857776,19861612,19864262,19864269,19864323,19864410,19864561,19864688,19865268,19866075,19866417,19866494,19867776,19908449],"created_at":"2019-05-08T11:17:08Z","created_at_i":1557314228,"num_comments":64,"objectID":"19857744","points":183,"story_id":19857744,"title":"Post-mortem and remediations for the Matrix.org security breach","updated_at":"2024-09-20T04:14:23Z","url":"https://matrix.org/blog/2019/05/08/post-mortem-and-remediations-for-apr-11-security-incident/"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"rhaksw"},"story_text":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"Hi HN, this talk represents a summary of my work over the last four years on addressing shadow moderation with Reveddit.

Let me know what you think, good or bad, and I'll do my best to answer.

What is shadow moderation? It is any action taken against your content that you aren't told about and aren't able to detect while logged in. I focus on Reddit comments since every single removal is shadow removed\u2014 removed comments are shown to you as if they're not.

You can try this for yourself on,

https://www.reveddit.com

https://www.reddit.com/r/CantSayAnything/about/sticky/

Your content will be removed, you won't be told, and it will be shown to you as if it's publicly visible."},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"Show HN: Reveddit.com: Improving online discourse with transparent moderation"},"url":{"matchLevel":"none","matchedWords":[],"value":"https://cantsayanything.win/2022-10-transparent-moderation/?talk"}},"_tags":["story","author_rhaksw","story_33475391","show_hn"],"author":"rhaksw","children":[33478193,33478239,33478435,33478683,33478795,33478815,33478884,33479235,33479408,33480630,33480631,33480670,33480775,33480843,33480884,33481246,33483294,33483474,33483700,33484183],"created_at":"2022-11-04T23:13:28Z","created_at_i":1667603608,"num_comments":185,"objectID":"33475391","points":180,"story_id":33475391,"story_text":"Hi HN, this talk represents a summary of my work over the last four years on addressing shadow moderation with Reveddit.

Let me know what you think, good or bad, and I'll do my best to answer.

What is shadow moderation? It is any action taken against your content that you aren't told about and aren't able to detect while logged in. I focus on Reddit comments since every single removal is shadow removed\u2014 removed comments are shown to you as if they're not.

You can try this for yourself on,

https://www.reveddit.com

https://www.reddit.com/r/CantSayAnything/about/sticky/

Your content will be removed, you won't be told, and it will be shown to you as if it's publicly visible.","title":"Show HN: Reveddit.com: Improving online discourse with transparent moderation","updated_at":"2026-03-19T15:47:26Z","url":"https://cantsayanything.win/2022-10-transparent-moderation/?talk"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"zdw"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"How do you know when macOS detects and remediates malware?"},"url":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"https://eclecticlight.co/2023/01/04/how-do-you-know-when-macos-detects-and-remediates-malware/"}},"_tags":["story","author_zdw","story_34249018"],"author":"zdw","children":[34249992,34250042,34250154,34250255,34250288,34250303,34250936,34251042,34251152,34252624,34252692,34254375,34256416,34256778],"created_at":"2023-01-04T17:59:17Z","created_at_i":1672855157,"num_comments":111,"objectID":"34249018","points":175,"story_id":34249018,"title":"How do you know when macOS detects and remediates malware?","updated_at":"2024-09-20T13:01:35Z","url":"https://eclecticlight.co/2023/01/04/how-do-you-know-when-macos-detects-and-remediates-malware/"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"JumpCrisscross"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"Cities Experiment with Remedy for Poverty: Cash, No Strings Attached"},"url":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"https://www.wsj.com/articles/cities-experiment-with-remedy-for-poverty-cash-no-strings-attached-11601371801"}},"_tags":["story","author_JumpCrisscross","story_24627073"],"author":"JumpCrisscross","children":[24627382,24627401,24627440,24628064,24628089,24628180,24628215,24628278,24628498,24628510,24628551,24628992,24630120,24630237,24630342,24632397,24632645,24632723,24633097,24633296,24633474,24633905,24634816,24634831,24636424],"created_at":"2020-09-29T12:49:39Z","created_at_i":1601383779,"num_comments":315,"objectID":"24627073","points":154,"story_id":24627073,"title":"Cities Experiment with Remedy for Poverty: Cash, No Strings Attached","updated_at":"2025-10-11T21:03:02Z","url":"https://www.wsj.com/articles/cities-experiment-with-remedy-for-poverty-cash-no-strings-attached-11601371801"},{"_highlightResult":{"author":{"matchLevel":"none","matchedWords":[],"value":"anythingnonidin"},"title":{"fullyHighlighted":false,"matchLevel":"full","matchedWords":["revmed"],"value":"Ecstasy as a Remedy for PTSD? 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